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Staff Scientist - Tumor Immunology

City of Hope

City of Hope

Posted on Thursday, July 11, 2024

Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research.

The laboratory of Dr. Heather McGee, MD, PhD, Assistant Professor in the Departments of Radiation Oncology and Immuno-Oncology, is seeking to hire a Staff Scientist with experience in immunology, tumor immunology and/or innate immunity. Dr. McGee leads an exciting and dynamic research group at the forefront of studies on the immune response to radiation.

The focus of the lab is to understand how radiation activates tissue resident immune cells in various tumor microenvironments. Their goals are to identify key molecular and immunologic pathways activated by radiation that can be targeted to enhance anti-tumor immunity and/or minimize normal tissue toxicity for gastrointestinal (GI) malignancies. In addition, we have discovered a novel immune-mediated mechanism that contributes to the development of early-onset colorectal cancer and are investigating the epigenetic and transcriptional regulation of this pathway. This is an outstanding opportunity for a very motivated and ambitious scientist to thrive and obtain first-author publications and grants that will allow him or her to become an independent Principal Investigator in the future.

For more information on Dr. McGee’s research please visit here.

As a successful candidate, you will:

· Devise, plan, and contribute original ideas to basic science and translational projects in one or more of the following four areas:

o 1) immune response to radiation in the liver tumor microenvironment

o 2) immune determinants of early-onset colorectal cancer

o 3) radiation-induced natural killer cell (NK cell) activation

o 4) radiation-induced cell death pathways in GI cancers.

· Collect data for figures to be used for lab meetings and grant applications.

· Prepare manuscripts for publication with Dr. McGee.

· Work in close collaboration with other team members and both internal and external collaborators.

· Train and supervise junior scientists in the lab.

Qualifications

· The Staff Scientist must possess, at a minimum, the U.S. equivalent Bachelor’s or Master’s degree in an appropriate discipline, and will often have a Ph.D. or other doctoral level degree.

· Experience in tumor immunology and flow cytometry.

· Evidence of scientific rigor and excellence as documented by first author high-impact peer-reviewed publications.

· Previous experience working with animal models (transgenic and knock-in reporter mice).

· Strong team player with excellent communication skills and fluency in English (both spoken and written).

Preferred qualifications:

· Priority consideration will be given to candidates who possess a Ph.D. and have at least 3 years of experience.

City of Hope is an equal opportunity employer. To learn more about our commitment to diversity, equity and inclusion, please click here.

To learn more about our Comprehensive Benefits, please CLICK HERE.